St. Lucy's Home for Girls Raised by Wolves tells the story of a group of girls, raised by wolves, who are brought to a Catholic orphanage to be assimilated into human society. The nuns at St. Lucy's, guided by a "Jesuit Handbook on Lycanthropic Culture Shock," attempt to transform the girls into human girls through a series of stages. The girls struggle with this process, and the story explores themes of identity, culture shock, and the tension between nature and nurture.